ICNC Abstracts, ICNC 2018

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Clinico-radiologic spectrum and outcome of pediatric demyelinating disorders – A retrospective study
Bidisha Banerjee, Muhammed Valikandy Hafis, Ullas V Acharya

Last modified: 2018-09-09


Introduction: Acquired demyelinating disorders(ADS) constitute treatable cause of acute neurological illness. National data regarding spectrum and outcome of pediatric demyelinating diseases is limited, hence the study 1.

Methods: Retrospective chart review of patients with ADS at pediatric-neurology division between January 2010 to 2018 was done. Neuroradiologist reviewed MRI. Diagnosis revised as per IPMSSG definitions2.

Results: Forty-three patients, mean age 7.75 years, 27 boys, 16 girls included. Eleven had acute disseminated encephalomyelitis (ADEM), 10 neuromyelitis-optica-spectrum disease (NMOSD), 22 clinically-isolated-syndrome (CIS) including 6 optic-neuritis(ON), 5 brainstem-demyelination, 3 transverse-myelitis (TM), 2 each tumefactive-demyelination/others and 4 polyfocal. White-matter lesions seen in (46.5%), brainstem lesions (45%), basal ganglia and thalami (30%), spinal cord lesions (22.5%), corpus callosum (13.9%), optic nerve and area postrema (11.6%). At median follow-up of 10.6 months complete recovery occurred in 67.4%, abnormal neuroexam without functional limitation (ataxia, scoliosis, amblyopia) in 11.60%, neurodeficits in 9.3%. All with ADEM were normal, 70 % with NMOSD had no significant neurodeficits and 59% of CIS had complete recovery with neurologic signs in 36.3%. Relapse was seen in 5, all within 6 months of first episode; 4 had NMOSD. Follow- up scans reviewed in 10; 5 were normal and 5 showed resolving lesions.

Conclusion: Higher proportion of CIS than ADEM, relatively more NMOSD seen. Brainstem lesions common. Good outcome with few early relapses in NMOSD.


1. Gulati S. Ann Indian Acad Neurol 2015 Sep;18: S48-55

2. Tenembaum S. Neurology; 87: S59-66


pediatric demyelination;NMOSD

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