ICNC Abstracts, ICNC 2018

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Clinicoetiological profile and outcome of convulsive status epilepticus in children
Rajwanti Kishore Vaswani, Sayoni RoyChowdhury

Last modified: 2018-09-09

Abstract


Introduction: Convulsive status epilepticus (CSE) , the most common life-threatening neurological emergency in children  is associated with significant neurological sequelae.

Objectives: To determine  the  clinicoetiological  profile,  outcome of CSE and to identify factors affecting the outcome.

Methods: The prospective study was carried out over 18 months in children aged 1 month to 12 years. Etiological factors were categorized into 5 groups: idiopathic, acute symptomatic, remote symptomatic, febrile and progressive encephalopathy. Immediate outcome and outcome at discharge were assessed. Chi Square and Fishers` exact test were applied for statistical analysis.

Results : Of the 120 children, the most common etiology of CSE was acute symptomatic (46, 38%) followed by remote symptomatic (37, 30.3%). In infants and children  more than 6 years, the prime etiology of CSE was acute symptomatic, compared to remote symptomatic in children aged 1 to 6 years(p<0.001). Poor immediate outcome was seen in 50 children (41.7%); primarily due to progressive encephalopathy (100%) and remote symptomatic etiologies (64.9%). The association between etiologies  of  CSE and  immediate outcome was statistically significant (p<0.001). Poor functional outcome at discharge was observed most commonly in infants (82%) and with progressive encephalopathy and remote symptomatic etiologies. The mean duration of CSE in children with poor functional outcome was significantly prolonged (p<0.0001).

Conclusion: Age of the child was one of the main determinants of etiology of CSE. The etiology and duration of CSE were the significant predictors of outcome of CSE in children.

 

 


Keywords


convulsive status epilepticus; etiology;outcome;children

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