ICNC Abstracts, ICNC 2018

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Clinical & Neuro-Imaging Changes of Subacute sclerosing panencephalitis- Experience 30 Cases in Tertiary Care Center in Bangladesh
Gopen Kumar Kundu

Last modified: 2018-09-09


Background: Subacute sclerosing panencephalitis (SSPE) is a fatal progressive neurological disorder of childhood and early adolescence. It is a slow virus disease caused by persistent defective measles virus infection of the brain.

Objective: To see the clinical and  neuro-imaging findings in children with Subacute Sclerosing Panencephalitis.

Methods: This retrospective study was conducted at BSMMU, Dhaka, a tertiary care center in Bangladesh. Thirty SSPE children were evaluated at paediatric neurology ward during the period January 2010 to December 2017. Diagnosis was based on the characteristic clinical features of progressive cognitive or behavioural changes, myoclonus, electroencephalographic evidence and raised IgG anti-measles antibody in CSF.

Results: Mean age was 10.2 ± 3.1 year and male female ratio was 5:1 among 30 patients, Most of the patient arrived from poor socio-economic (83.33%) background of rural area(66.67%) of Bangladesh.  Among them 46.67% had history of measles infection during early childhood . All of the patients(100%)  showed positive measles specific antibody IgG in CSF and On electroencephalographic findings showed periodic burst suppression in 90.90% cases. Most of the children (56.6%) were in stage II category and other 3.3%, 33.3%, 6.6%,were stage-I,stage- III, stage-IV category respectively. Neuroimmaging study showed abnormalities in 45.83% cases  included periventricular white matter hyper intense signal changes, cortical atrophy and ischaemic change.


Conclusion: In our study most of the SSPE patients were in stage II. Neuroimmaging abnormalities found in about half of the patients and commonest finding was periventricular white matter hyper intense signal changes.

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