ICNC Abstracts, ICNC 2018

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Preliminary Magnetoencephalography (MEG) Findings of Somatosensory Gating Using Dual-Pulse Sensory Tactile Stimulation in Dystonic Children with Basal Ganglia Stroke
Nomazulu Dlamini, Ahmad Mousa, Cecilia Jobst, Sabah Master, Gabrielle deVeber, Douglas Cheyne

Last modified: 2018-09-09

Abstract


INTRODUCTION: Children recover from the damaging effects of stroke three times better than adults, but are one hundred times more likely to incur a maladaptive recovery, including dystonia – the most common post-stroke movement disorder. Post-stroke therapies involving repetitive tactile stimulation demonstrate improved sensory function, but it is not clear what oscillatory changes occur. Somatosensory Evoked Fields (SEF) – magnetic brain responses to somatosensory input, are a useful measure of somatosensory processing and altered SEFs have been previously reported in children with cerebral palsy. In this study, we assessed somatosensory function in post-stroke dystonic children by measuring sensory gating during a paired-pulse tactile stimulus task. We predicted altered gating responses (enhanced or reduced amplitude to the second pulse) in the affected pathways.

METHODS: Magnetoencephalography (MEG) was collected at 600 samples/s in four children (2 females, mean age 15.25 ± 1.71 y.o.) with unilateral basal ganglia stroke and dystonic features (2 left-side affected). A 30 psi pneumatic-driven stimulus was presented to left and right index fingers (ISI 2s, with 350ms between dual-pulses) for 8-10 minutes. Event-related sensory response peaks were localized for each averaged pulse within the sensorimotor cortex at approximately 40ms latency. Time course plots were created for each peak.

RESULTS: Preliminary results show a clear reduced gating to the secondary pulse or delayed sensory response latencies only in the affected hand in all 4 children.

CONCLUSIONS: These findings provide initial evidence for stimulus deficits in dystonic children, with therapeutic measures to be explored further with MEG techniques.

References

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Keywords


Neuroimaging; Childhood Stroke; Movement Disorders

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