ICNC Abstracts, ICNC 2018

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clinical features of Myelin oligodendrocyte glycoprotein(MOG)antibody positive cetral nervous system inflammatory dymyelination in 31 children
Zhang wh

Last modified: 2018-09-09


Purpose:To discribe clinical features of  MOG-antibody positive pediatric cetral nerve system inflammatory dymyelination

Method:Retrospectively analyze  31 patients diagnosed as central nervous system inflammatory demyelinating diseases with positive serum MOG-antibody between January 2017 and March 2018;.

Result: 31 cases were  included,sex ratio M: F=15: 16.Age of onset ranged from 5 months to 12 years and 2 months old, average age of onset was (7.2±4.4) years old (male 7.7±4.6, female 6.8+±4.4), and no significant difference between genders. 17 cases were  monophasic, including acute disseminated encephalomyelitis 9 cases, optic neuritis 3 cases, clinical isolated syndrome 4 cases ,unknown classification 1case. 14 cases were recurrent. The clinical phenotypes were multiple phasic disseminated encephalomyelitis 5 cases, of multiple sclerosis 4 cases,and 5 cases could not be classified. The most commom presentation of this group in first demyelinating event was fever (15/31), encephalopathy (14/31), and visual loss (12/31) . Brainstem (15/31), basal ganglia (15/31), cerebellum (13/31), cortex (13/31), and subcortical white matter (12/31) were the  most frequent involved in the first demyelination event.Follow up from 2 month to 1.4 year. All except one ADEM case  have no movement disorders, intellectual retardation or visual impairment.

Conclusion: Children's central nervous system inflammatory demyelinating diseases can be mediated by MOG antibodies, cThe majority of the prognosis is good, but the recurrence cases still need further study.


Myelin oligodendrocyte glycoprotein antibody ;central nervous inflammatory dymyelination; pediatric

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