ICNC Abstracts, ICNC 2018

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Mineralizing Angiopathy- A case series of 5 cases.
Anand GAJAJNAN DIWAN

Last modified: 2018-09-09

Abstract


Introduction-Pediatric strokes are multifactorial in etiology and extensive work up for pediatric stroke is mandatory. Detailed history of trauma is necessary. Basal ganglia stroke following trivial head trauma is known in children.

Methods- A case series of 5 infants-toddlers (age 6-24mths), F-1, M-4, who presented with hemiparesis following transient head trauma due to fall from bed or swing without significant external head trauma.  One child showed focal seizures. All children showed good recovery from hemiparesis. Aspirin 2mg/kg were given to 2 children for 3mths.

Results- table and fig attached

Discussion- The possible mechanisms of stroke following trivial trauma are - transient arterial spasm, mechanical disruption of perforating arteries, and subsequent thrombosis. Lenticulostriate vessel have acute angle at origin from the middle cerebral artery which predispose these vessels to stretching, and distorting forces after trivial head trauma.[1]  Elasticity of the pediatric skull, makes the shearing forces  stronger. Basal ganglia calcifications in infants with stroke following trivial trauma is  identified as the potential risk factor. [2] The exact mechanism by which calcification was contributing to the development of stroke was largely unknown. Age predisposed (6-24mths), trauma-related stress across the mineralized lenticulostriate vessels may thrombosis with subsequent stroke. Distinct clinic-radiological entity of mineralizing Angiopathy shows classical phenotype of a previously healthy 6-24-months-old infant with basal ganglia stroke following trivial trauma, with or without transient hemidystonia, linear mineralization along lenticulostriate arteries, and good short-term neurodevelopment outcome.[3]


Keywords


Stroke, trauma, mineralising angiopathy

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